Hsd17b1 Gene Summary [Mouse]
Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; estradiol 17-beta-dehydrogenase [NAD(P)+] activity; and testosterone dehydrogenase [NAD(P)+] activity. Involved in estrogen biosynthetic process and testosterone biosynthetic process. Acts upstream of or within several processes, including adipose tissue development; lysosome organization; and skeletal muscle tissue development. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; reproductive system; spleen; submandibular gland; and trachea. Orthologous to human HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsd17b1 |
| Official Name | hydroxysteroid (17-beta) dehydrogenase 1 [Source:MGI Symbol;Acc:MGI:105077] |
| Ensembl ID | ENSMUSG00000019301 |
| Bio databases IDs | |
| Aliases | hydroxysteroid (17-beta) dehydrogenase 1 |
| Synonyms | 17-beta-HSD, 17beta-hydroxysteroid dehydrogenase, 17-beta-HYDROXY-STEROID-DEHYDROGENASE isoform I, 17BHD1, 17b-HSD I, 17HSDB1, 17hsd/ksr1, 17-β-HSD, 17-β-HYDROXY-STEROID-DEHYDROGENASE isoform I, 20-alpha-HSD, 20-α-HSD, E2DH, EDH17B2, EDHB17, Estradiol 17-beta Dehydrogenase, Estradiol 17-β Dehydrogenase, HSD17, Hsd17ba, hydroxysteroid (17-beta) dehydrogenase 1, hydroxysteroid 17-beta dehydrogenase 1, hydroxysteroid (17-β) dehydrogenase 1, hydroxysteroid 17-β dehydrogenase 1, SDR28C1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsd17b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- 3(or 17)beta-hydroxysteroid dehydrogenase
- estradiol 17beta-dehydrogenase
- KR domain
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- protein binding
- steroid binding
- polyketide synthase keto reductase domain
- 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD)
- binding protein
- NADP binding
- CH-OH group:NAD or NADP oxidoreductase
- protein homodimerization
- short chain dehydrogenase
- steroid dehydrogenase
Pathways
Biological processes and signaling networks where the Hsd17b1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- diabetes mellitus
- organismal death
- depressive disorder
role in cell
- quantity
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsd17b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- estrogen biosynthetic process
- lysosome organization
- estrogen metabolic process
- skeletal muscle tissue development
- cellular response to metal ion
- gene expression
- testosterone biosynthetic process
- steroid biosynthetic process
- adipose tissue development
- bone development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- dihydrotestosterone 17-beta-dehydrogenase activity
- testosterone dehydrogenase [NAD(P)] activity
- small molecule binding
- steroid binding
- estradiol 17-beta-dehydrogenase activity
- 17-beta-hydroxysteroid dehydrogenase (NADP+) activity
- NADP binding
- protein binding
- catalytic activity
- testosterone dehydrogenase (NAD+) activity
- testosterone 17-beta-dehydrogenase (NADP+) activity
- NADP+ binding