Slc25a1 Gene Summary [Mouse]
Predicted to enable citrate secondary active transmembrane transporter activity. Predicted to be involved in mitochondrial citrate transmembrane transport. Located in mitochondrion. Is expressed in several structures, including connective tissue; gut; liver; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; combined D-2- and L-2-hydroxyglutaric aciduria; and congenital myasthenic syndrome. Orthologous to human SLC25A1 (solute carrier family 25 member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a1 |
| Official Name | solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 [Source:MGI Symbol;Acc:MGI:1345283] |
| Ensembl ID | ENSMUSG00000003528 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 |
| Synonyms | 1300019P08Rik, 2610100G11Rik, AI194714, CIC, Citrate transport, CMS23, CTP, D2L2AD, Dgsj, MCTP, SEA, SLC20A3, solute carrier family 25 member 1, solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1, Tcc, Tricarboxylate carrier (mitochondrial), Tricarboxylate transport |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc25a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitochondrial carrier protein
- tricarboxylic acid transporter
- tricarboxylate carrier
- transporter
- citrate transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- Huntington disease
- organismal death
- presynaptic congenital myasthenic syndrome type 23
- COVID-19
- lung adenocarcinoma formation
- tumorigenesis
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
role in cell
- expression in
- apoptosis
- proliferation
- colony formation
- hypermotility
- accumulation in
- synthesis in
- oxidative phosphorylation in
- acetylation in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc25a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty-acyl-CoA biosynthetic process
- gluconeogenesis
- mitochondrial citrate transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- citrate transmembrane transporter activity
- antiporter activity
- tricarboxylic acid transmembrane transporter activity
- citrate secondary active transmembrane transporter activity