Noct Gene Summary [Mouse]
Enables mRNA binding activity and poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of fat cell differentiation; and regulation of gene expression. Acts upstream of or within P-body assembly and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body; nucleus; and perinuclear region of cytoplasm. Is expressed in 2-cell stage embryo; central nervous system; and retina. Orthologous to human NOCT (nocturnin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Noct |
| Official Name | nocturnin [Source:MGI Symbol;Acc:MGI:109382] |
| Ensembl ID | ENSMUSG00000023087 |
| Bio databases IDs | |
| Aliases | nocturnin |
| Synonyms | Ccr4, CCR4C, CCR4L, CCRN4L, Ccrn4lb, NOC, nocturnin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Noct often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- poly(A)-specific ribonuclease
- mRNA binding
- NADP phosphatase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- phosphatase
- Endonuclease/Exonuclease/phosphatase family
- protein binding
Pathways
Biological processes and signaling networks where the Noct gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
role in cell
- differentiation
- expression in
- assembly
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic mRNA processing body
- Cytoplasm
- perinuclear region
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Noct gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of embryonic development
- transcription from RNA polymerase II promoter
- positive regulation of fat cell differentiation
- regulation of circadian rhythm
- negative regulation of osteoblast differentiation
- negative regulation of gene expression
- circadian regulation of gene expression
- mRNA stabilization
- NADP metabolic process
- cytoplasmic mRNA processing body assembly
- deadenylation-dependent decapping of nuclear-transcribed mRNA
- response to lipopolysaccharide
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- mitochondrion
- cytoplasmic mRNA processing body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- 3'-5'-exoribonuclease activity
- metal ion binding
- mRNA binding
- NADP phosphatase activity