Rab3b Gene Summary [Mouse]
Enables GTP-dependent protein binding activity. Acts upstream of or within peptidyl-cysteine methylation and regulation of exocytosis. Located in synaptic vesicle. Colocalizes with secretory granule. Is expressed in dentate gyrus subgranular zone and telencephalon. Orthologous to human RAB3B (RAB3B, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab3b |
| Official Name | RAB3B, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1917158] |
| Ensembl ID | ENSMUSG00000003411 |
| Bio databases IDs | |
| Aliases | RAB3B, member RAS oncogene family |
| Synonyms | 2610528C18Rik, RAB3B, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP-dependent protein binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- myosin binding
- ADP-ribosylation factor family
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rab3b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dyspnea
- small cell lung cancer
- cyanosis
role in cell
- number
- size
- activation
- autophagy in
- exocytosis by
- transmission
- paired-pulse facilitation
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- synaptic vesicle membrane
- perinuclear region
- Plasma Membrane
- vesicles
- insulin secretory granules
- synaptic vesicles
- synapse
- dense-core vesicles
- secretory granules
- presynaptic terminals
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of dopamine uptake involved in synaptic transmission
- antigen processing and presentation
- exocytosis
- protein secretion
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- endosome
- cytoplasm
- synaptic vesicle
- vesicle
- Golgi apparatus
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding
- myosin V binding