Sgsm2 Gene Summary [Mouse]
Enables GTPase activator activity. Predicted to be involved in late endosome to Golgi transport and positive regulation of GTPase activity. Located in melanosome. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human SGSM2 (small G protein signaling modulator 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgsm2 |
| Official Name | small G protein signaling modulator 2 [Source:MGI Symbol;Acc:MGI:2144695] |
| Ensembl ID | ENSMUSG00000038351 |
| Bio databases IDs | |
| Aliases | small G protein signaling modulator 2 |
| Synonyms | D630003G22Rik, mKIAA0397, RUTBC1, small G protein signaling modulator 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sgsm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- domain involved in Ras-like GTPase signaling
- Rab-binding domain (RBD)
- enzyme binding
- GTPase activator
- Pleckstrin homology-like domain
- RUN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- multiple sclerosis
- hypertension
- pervasive developmental disorder
- insomnia
- papillary thyroid cancer
- migraines
regulated by
- beta-estradiol
regulates
- ERK
- GTPase
- AKT
- RAP1
- RAB33B
role in cell
- phosphorylation in
- activation in
- proliferation
- migration
- invasion by
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- melanosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sgsm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- late endosome to Golgi transport
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- melanosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity
- small GTPase binding