Ddx39b Gene Summary [Mouse]
Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent protein binding activity; and RNA binding activity. Predicted to be involved in several processes, including gene expression; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of macromolecule biosynthetic process. Located in nuclear speck. Is expressed in brain and embryo. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human DDX39B (DExD-box helicase 39B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx39b |
| Official Name | DEAD box helicase 39b [Source:MGI Symbol;Acc:MGI:99240] |
| Ensembl ID | ENSMUSG00000019432 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 39b |
| Synonyms | 0610030D10Rik, BAT1, Bat1a, D17H6S81E, D17H6S81E-1, D6S81E, D6S81Eh, DEAD box helicase 39b, Dead Box RNA Helicase p47, DExD-box helicase 39B, p47, UAP56 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx39b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- U4 snRNA binding
- U6 snRNA binding
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- enzyme
- protein binding
- identical protein binding
- ATPase
- Helicase conserved C-terminal domain
- RNA helicase
- RNA dependent ATPase
- binding protein
- N-terminal helicase domain of the DEAD-box helicase superfamily
- ATP-dependent protein binding
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- liver cancer
- lung cancer
- myositis
- gastric carcinoma
- gastric epithelial cancer
- colon cancer
role in cell
- expression in
- survival
- formation
- formation in
- accumulation in
- mitomycin C sensitivity
- assembly
- cisplatin sensitivity
- olaparib sensitivity
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intranuclear region
- spliceosomes
- nucleoplasm
- nucleoli
- nuclear speckles
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx39b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- RNA splicing
- RNA export from nucleus
- RNA secondary structure unwinding
- spliceosomal complex assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- spliceosomal complex
- transcription export complex
- U6 snRNP
- nucleoplasm
- U4 snRNP
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- U6 snRNA binding
- ATP binding
- identical protein binding
- RNA binding
- protein binding
- RNA helicase activity
- RNA-dependent ATPase activity
- mRNA binding
- ATP-dependent protein binding
- U4 snRNA binding