Hipk3 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in negative regulation of JUN kinase activity; peptidyl-serine phosphorylation; and peptidyl-threonine phosphorylation. Located in PML body and cytoplasm. Is expressed in diaphragm; heart; limb segment; paraxial mesenchyme; and skeletal musculature. Orthologous to human HIPK3 (homeodomain interacting protein kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hipk3 |
| Official Name | homeodomain interacting protein kinase 3 [Source:MGI Symbol;Acc:MGI:1314882] |
| Ensembl ID | ENSMUSG00000027177 |
| Bio databases IDs | |
| Aliases | homeodomain interacting protein kinase 3 |
| Synonyms | ANPK, DYRK6, FIST, FIST3, homeodomain interacting protein kinase 3, mir-1902, PKY, YAK1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hipk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- protein kinase
- Protein Kinases, catalytic domain
- transcription co-repressor
- protein binding
- Protein kinase domain
- Fas binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- atherosclerosis
- schizophrenia
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- adult T-cell leukemia/lymphoma
- thyroid cancer
- hepatic steatosis
- lymphomagenesis
role in cell
- phosphorylation in
- cell viability
- expression in
- apoptosis
- migration
- deposition in
- migratory capacity
- replication in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nuclear bodies
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hipk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription
- negative regulation of JUN kinase activity
- negative regulation of apoptotic process
- apoptotic process
- protein phosphorylation
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- PML body
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein kinase activity
- protein serine/threonine kinase activity