Myl12b Gene Summary [Mouse]
Enables myosin heavy chain binding activity. Acts upstream of or within regulation of cell shape. Located in several cellular components, including Z disc; brush border; and stress fiber. Part of myosin II complex. Orthologous to several human genes including MYL12B (myosin light chain 12B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myl12b |
| Official Name | myosin, light chain 12B, regulatory [Source:MGI Symbol;Acc:MGI:107494] |
| Ensembl ID | ENSMUSG00000034868 |
| Bio databases IDs | |
| Aliases | myosin, light chain 12B, regulatory |
| Synonyms | 1500001M02Rik, MLC20, MLC-2A, MLC-B, Mlrb, MRLC2, Mylc2b, myosin light chain 12B, myosin, light chain 12B, regulatory, MYOSIN REGULATORY LIGHT CHAIN, Nrlc, RLC-B, Rmlc |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myl12b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin binding
- EF-hand, calcium binding motif
- EF-hand domain
- EF hand
- EF-hand domain pair
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- protein binding
Pathways
Biological processes and signaling networks where the Myl12b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Axonal Guidance Signaling
- Cardiac Hypertrophy Signaling
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- CXCR4 Signaling
- Ephrin A Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- IL-8 Signaling
- Integrin Signaling
- PAK Signaling
- Phagosome Formation
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apical compartment
- peripheral lamellae
- cell cortex
- Nucleus
- cytosol
- Z line
- actin stress fibers
- membrane rafts
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myl12b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
Cellular Component
Where in the cell the gene product is active
- Z disc
- extracellular vesicular exosome
- apical part of cell
- brush border
- cytoplasm
- cell cortex
- stress fiber
- myosin II complex
- cytosol
- myofibril
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- myosin heavy chain binding