Fuca2 Gene Summary [Mouse]
Predicted to enable alpha-L-fucosidase activity. Predicted to be involved in several processes, including fucose metabolic process; glycoside catabolic process; and regulation of entry of bacterium into host cell. Predicted to be located in extracellular space. Predicted to be active in lysosome. Is expressed in nervous system and respiratory system. Orthologous to human FUCA2 (alpha-L-fucosidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fuca2 |
| Official Name | fucosidase, alpha-L- 2, plasma [Source:MGI Symbol;Acc:MGI:1914098] |
| Ensembl ID | ENSMUSG00000019810 |
| Bio databases IDs | |
| Aliases | fucosidase, alpha-L- 2, plasma |
| Synonyms | 0610025O11RIK, 5530401P20Rik, alpha-L-fucosidase 2, dJ20N2.5, fucosidase, alpha-L- 2, plasma, fucosidase, α-L- 2, plasma, MGC1314, α-L-fucosidase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fuca2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha-L-fucosidase C-terminal domain
- Alpha amylase catalytic domain family
- enzyme
- protein binding
- alpha-L-fucosidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- epithelial cancer
- acute myeloid leukemia
- soft tissue sarcoma
- soft tissue sarcoma cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- organismal death
- rectal adenocarcinoma
- colorectal carcinomagenesis
regulates
- fucose
role in cell
- autophagy in
- cell viability
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- azurophil granule lumen
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fuca2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoside catabolic process
- response to bacterium
- regulation of entry of bacterium into host cell
- fucose metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- extracellular region
- azurophil granule lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- alpha-L-fucosidase activity