Gprc5b Gene Summary [Mouse]
Enables protein kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of neuron differentiation; and positive regulation of signal transduction. Acts upstream of or within several processes, including glucose homeostasis; positive regulation of neuron projection development; and positive regulation of protein kinase activity. Located in cell surface. Is active in membrane raft. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts. Orthologous to human GPRC5B (G protein-coupled receptor class C group 5 member B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gprc5b |
| Official Name | G protein-coupled receptor, family C, group 5, member B [Source:MGI Symbol;Acc:MGI:1927596] |
| Ensembl ID | ENSMUSG00000008734 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor, family C, group 5, member B |
| Synonyms | G protein-coupled receptor class C group 5 member B, G protein-coupled receptor, class C, group 5, member B, G protein-coupled receptor, family C, group 5, member B, Loc293546, MLC3, RAIG-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gprc5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- protein kinase activator
- protein kinase binding
- protein kinase inhibitor activity
- G-protein-coupled receptor binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gprc5b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute kidney injury
- weight gain
- megalencephalic leukoencephalopathy with subcortical cysts 3
- colon adenocarcinoma
- colon epithelial cancer
- rotator cuff injury
role in cell
- growth
- development
- differentiation
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- cytosol
- nucleoplasm
- nucleoli
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gprc5b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macrophage cytokine production
- G-protein coupled receptor signaling pathway
- positive regulation of protein tyrosine kinase activity
- positive regulation of inflammatory response
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of neuron differentiation
- cell volume homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasmic vesicle membrane
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- cytosol
- receptor complex
- nucleolus
- plasma membrane
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- G-protein coupled receptor activity
- protein kinase binding
- protein kinase activator activity