Tnpo2 Gene Summary [Mouse]
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Acts upstream of or within negative regulation of muscle cell differentiation and protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; gallbladder; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies. Orthologous to human TNPO2 (transportin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnpo2 |
| Official Name | transportin 2 (importin 3, karyopherin beta 2b) [Source:MGI Symbol;Acc:MGI:2384849] |
| Ensembl ID | ENSMUSG00000031691 |
| Bio databases IDs | |
| Aliases | transportin 2 (importin 3, karyopherin beta 2b) |
| Synonyms | 1110034O24Rik, IDDHISD, IPO3, Knpb2b, KPNB2B, transportin 2, transportin 2 (importin 3, karyopherin beta 2b), transportin 2 (importin 3, karyopherin β 2b), TRN2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnpo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT-like repeat
- protein binding
- Importin-beta N-terminal domain
- nuclear localization sequence binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder
- hereditary disorder
- intellectual developmental disorder with hypotonia, impaired speech and dysmorphic facies
- multiple sclerosis
role in cell
- expression in
- activation in
- cell death
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnpo2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- nuclear localization sequence binding