Usp21 Gene Summary [Mouse]
Enables cysteine-type deubiquitinase activity and transcription coactivator activity. Involved in transcription initiation-coupled chromatin remodeling. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in left lung; primary oocyte; right lung; and submandibular gland primordium. Orthologous to human USP21 (ubiquitin specific peptidase 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp21 |
| Official Name | ubiquitin specific peptidase 21 [Source:MGI Symbol;Acc:MGI:1353665] |
| Ensembl ID | ENSMUSG00000053483 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 21 |
| Synonyms | ESTM28, LOC678925, ubiquitin specific peptidase 21, USP16, USP23 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine-type peptidase
- NEDD8-specific protease
- transcription co-activator
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Peptidase_C19
- ubiquitin-specific thiol-proteases domain
Pathways
Biological processes and signaling networks where the Usp21 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- asthma
- epithelial cancer
- pancreatic epithelial cancer
- splenomegaly
- epithelial neoplasia
- preeclampsia
- ductal pancreatic cancer
- pancreatic cancer
- pancreatic neoplasia
role in cell
- expression in
- growth
- migration
- phosphorylation in
- production in
- proliferation
- polyubiquitination in
- binding in
- activation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression, epigenetic
- positive regulation of transcription, DNA-dependent
- proteolysis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- transcription coactivator activity
- metal ion binding
- NEDD8-specific protease activity
- cysteine-type peptidase activity