Rev3l Gene Summary [Mouse]
Predicted to enable DNA-directed DNA polymerase activity. Acts upstream of or within DNA repair. Located in nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and nose. Orthologous to human REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rev3l |
| Official Name | REV3 like, DNA directed polymerase zeta catalytic subunit [Source:MGI Symbol;Acc:MGI:1337131] |
| Ensembl ID | ENSMUSG00000019841 |
| Bio databases IDs | |
| Aliases | REV3 like, DNA directed polymerase zeta catalytic subunit |
| Synonyms | POLZ, Pol ζ, Rev, REV3, REV3 like, DNA directed polymerase zeta catalytic subunit, REV3 like, DNA directed polymerase ζ catalytic subunit, Sez4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rev3l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-directed DNA polymerase
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- DNA polymerase type-B family
- seatbelt-binding motif
- Domain of unknown function (DUF4683)
- enzyme
- protein binding
- DNA polymerase family B
- POLBc
- C4-type zinc-finger of DNA polymerase delta
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- major depression
- colorectal cancer
- colon epithelial cancer
- colorectal carcinomagenesis
- colon cancer
- large intestine cancer
- colorectal neoplasia
role in cell
- survival
- apoptosis
- cell death
- cell viability
- synthesis in
- recruitment in
- S phase
- formation
- formation in
- aberration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rev3l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication
- double-strand break repair via homologous recombination
- error-prone translesion synthesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- zeta DNA polymerase complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- DNA binding
- DNA-directed DNA polymerase activity
- protein binding
- metal ion binding
- 4 iron, 4 sulfur cluster binding