Psme3 Gene Summary [Mouse]
Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; endopeptidase activator activity; and p53 binding activity. Predicted to be involved in negative regulation of extrinsic apoptotic signaling pathway; regulation of G1/S transition of mitotic cell cycle; and regulation of proteasomal protein catabolic process. Predicted to be located in cytosol. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in genitourinary system and ventricular layer. Orthologous to human PSME3 (proteasome activator subunit 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psme3 |
| Official Name | proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) [Source:MGI Symbol;Acc:MGI:1096366] |
| Ensembl ID | ENSMUSG00000078652 |
| Bio databases IDs | |
| Aliases | proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) |
| Synonyms | AA410043, Ab2-371, HEL-S-283, Ki, Ki Nuclear Autoantigen, PA28G, PA28-gamma, PA28-γ, proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki), proteaseome (prosome, macropain) activator subunit 3 (PA28 γ, Ki), proteasome activator subunit 3, Proteasome (prosome, macropain) activator subunit 3 (pa28 γ), REG-GAMMA, REG-γ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psme3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- p53 binding
- protein binding
- enzyme regulator activity
- protease activator
- Proteasome activator pa28 beta subunit
- identical protein binding
- Proteasome activator pa28 alpha subunit
Pathways
Biological processes and signaling networks where the Psme3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- liver cancer
- tumorigenesis
- hepatic steatosis
- Waldenström macroglobulinemia
- growth failure
- premature aging
- liver neoplasia
role in cell
- proliferation
- expression in
- apoptosis
- phosphorylation in
- differentiation
- formation
- cell viability
- accumulation in
- number
- cell saturation density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- Nucleus
- basal bodies
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psme3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of proteasomal protein catabolic process
- apoptotic process
- negative regulation of extrinsic apoptotic signaling pathway
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- proteasome complex
- proteasome activator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- identical protein binding
- p53 binding
- protein binding