Polh Gene Summary [Mouse]
Enables DNA-directed DNA polymerase activity. Acts upstream of or within cellular response to UV-C; postreplication repair; and pyrimidine dimer repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus; replication fork; and site of double-strand break. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; liver; and lung. Used to study xeroderma pigmentosum variant type. Human ortholog(s) of this gene implicated in female breast cancer and xeroderma pigmentosum variant type. Orthologous to human POLH (DNA polymerase eta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polh |
| Official Name | polymerase (DNA directed), eta (RAD 30 related) [Source:MGI Symbol;Acc:MGI:1891457] |
| Ensembl ID | ENSMUSG00000023953 |
| Bio databases IDs | |
| Aliases | polymerase (DNA directed), eta (RAD 30 related) |
| Synonyms | DNA polymerase eta, POL ETA, polymerase (DNA directed), eta (RAD 30 related), RAD30, RAD30A, XP-V |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBZ domain
- PCNA binding domain
- damaged DNA binding
- DNA-directed DNA polymerase
- PCNA-interacting protein box
- Ubiquitin-Binding Zinc Finger
- nuclear localization sequence
- enzyme
- protein binding
- zinc finger domain
- impB/mucB/samB family
- Y-family of DNA polymerases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- squamous cell cancer
- epithelial neoplasia
- cancer
- neoplasia
- variant type xeroderma pigmentosum
- xeroderma pigmentosum
- hereditary disorder
role in cell
- quantity
- function
- proliferation
- phosphorylation in
- killing
- binding in
- growth
- survival
- replication in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic aggregates
- cytosol
- nuclear foci
- nucleoplasm
- DNA replication foci
- chromatin
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- cellular response to UV-C
- pyrimidine dimer repair
- DNA replication
- regulation of DNA repair
- response to radiation
- error-prone translesion synthesis
- response to UV-C
- DNA synthesis involved in DNA repair
- error-free translesion synthesis
Cellular Component
Where in the cell the gene product is active
- replication fork
- nucleus
- site of double-strand break
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA-directed DNA polymerase activity
- protein binding
- metal ion binding
- damaged DNA binding