Pttg1 Gene Summary [Mouse]
Enables cysteine-type endopeptidase inhibitor activity. Acts upstream of or within homologous chromosome segregation; mitotic sister chromatid cohesion; and smoothened signaling pathway. Located in cytoplasm and nucleus. Is active in axoneme. Is expressed in several structures, including central nervous system; eye; limb; mesonephric tubule of male; and testis. Orthologous to several human genes including PTTG1 (PTTG1 regulator of sister chromatid separation, securin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pttg1 |
| Official Name | pituitary tumor-transforming gene 1 [Source:MGI Symbol;Acc:MGI:1353578] |
| Ensembl ID | ENSMUSG00000020415 |
| Bio databases IDs | |
| Aliases | pituitary tumor-transforming gene 1 |
| Synonyms | EAP1, ECRAR, HPTTG, pituitary tumor-transforming gene 1, PITUITARY TUMOR TRANSFORMING GENE protein1, Pituitary tumour transforming 1, pituitary tumour-transforming gene 1, PITUITARY tumour TRANSFORMING GENE protein1, PTTG, PTTG1 regulator of sister chromatid separation, securin, Pttg3, Securin, TUTR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pttg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine protease inhibitor activity
- transcription regulator
- Securin sister-chromatid separation inhibitor
- destruction box
- heat shock protein binding
- ribosome binding
- protein binding
- PXXP motif
- KEN box
- phosphorylation site
Pathways
Biological processes and signaling networks where the Pttg1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- lung adenocarcinoma formation
- non-small cell lung cancer
- epithelial cancer
- neoplasia
- metastasis
- hyperplasia
- adenoma formation
- diabetes mellitus
- cholangiocarcinoma cancer
role in cell
- expression in
- activation in
- proliferation
- apoptosis
- cell death
- growth
- quantity
- synthesis in
- cell viability
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cilia
- Plasma Membrane
- axonemes
- asters
- cytosol
- chromosome
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pttg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- DNA repair
- chromosome organization
- spermatogenesis
- homologous chromosome segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- cysteine-type endopeptidase inhibitor activity
- SH3 domain binding