Rtn4 Gene Summary [Mouse]
Enables lipid binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of leukocyte migration; and vasculogenesis. Acts upstream of or within blastocyst formation; cardiac epithelial to mesenchymal transition; and nervous system development. Located in cell projection; endoplasmic reticulum membrane; and postsynaptic density. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including central nervous system; genitourinary system; limb mesenchyme; sensory organ; and skeletal musculature. Orthologous to human RTN4 (reticulon 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rtn4 |
| Official Name | reticulon 4 [Source:MGI Symbol;Acc:MGI:1915835] |
| Ensembl ID | ENSMUSG00000020458 |
| Bio databases IDs | |
| Aliases | reticulon 4 |
| Synonyms | 1110020G17Rik, ASY, C130026I10Rik, mKIAA0886, mKIAA4153, Nbla00271, Nbla10545, NgA, NI220/250, NOGO, Nogo-A, Nogo A/B, NSP, NSP-CL, reticulon 4, RTN-X, Vp20 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rtn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- extracellular domain
- lipid binding
- Reticulon
- nogo-a-specfic domain
- ectodomain
- metal ion binding
- lumenal/extracellular domain
- inhibitory domain
- protein binding
- BN domain
- binding protein
- nogo 66 domain
- Nogo-A delta 20 domain
- protein homodimerization
- cadherin binding
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Rtn4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- cerebral infarction
- atherosclerosis
- metabolic syndrome X
- acute coronary syndrome
- Alzheimer disease
- restenosis
- obesity
- Parkinson disease
- schizophrenia
role in cell
- expression in
- proliferation
- activation in
- phosphorylation in
- apoptosis
- production in
- growth
- transmembrane potential
- expansion
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- myelin enriched fraction
- nuclear fraction
- membrane fraction
- mitochondrial fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell junction
- endoplasmic reticulum tubules
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- postsynaptic region
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- axoplasm
- endoplasmic reticulum membrane
- microsome
- membrane ruffles
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- nuclear envelope
- dendritic spines
- myelin sheath outer loop
- synaptic vesicles
- axo-glial junction
- growth cone
- neurites
- paranodes
- myelin sheath inner loop
- myelin sheath
- synapse
- cellular protrusions
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rtn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebral cortex radial glia guided migration
- neuron differentiation
- positive regulation of toll-like receptor 9 signaling pathway
- regulation of branching morphogenesis of a nerve
- cellular sphingolipid homeostasis
- cardiac epithelial to mesenchymal transition
- regulation of apoptotic process
- nuclear pore complex assembly
- brain development
- axonal fasciculation
- negative regulation of axon extension
- negative regulation of cell growth
- apoptotic process
- blastocyst formation
- endoplasmic reticulum tubular network assembly
- regulation of synaptic transmission
- endoplasmic reticulum tubular network organization
- positive regulation of epithelial cell migration
- protein stabilization
- positive regulation of protein kinase B signaling cascade
- positive regulation of mammary gland epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- postsynaptic density
- anchoring junction
- endoplasmic reticulum tubular network
- endoplasmic reticulum
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding
- RNA binding
- cadherin binding