Nck2 Gene Summary [Mouse]
Enables scaffold protein binding activity. Involved in negative regulation of transcription by RNA polymerase II; regulation of response to endoplasmic reticulum stress; and regulation of translation in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including actin filament organization; ephrin receptor signaling pathway; and lamellipodium assembly. Located in vesicle membrane. Is expressed in several structures, including central nervous system; chordamesoderm; gut endoderm; hemolymphoid system gland; and paraxial mesenchyme. Orthologous to human NCK2 (NCK adaptor protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nck2 |
| Official Name | non-catalytic region of tyrosine kinase adaptor protein 2 [Source:MGI Symbol;Acc:MGI:1306821] |
| Ensembl ID | ENSMUSG00000066877 |
| Bio databases IDs | |
| Aliases | non-catalytic region of tyrosine kinase adaptor protein 2 |
| Synonyms | 4833426I10RIK, GRB4, LOC100503894, NCK adaptor protein 2, NCKbeta, Nck β, non-catalytic region of tyrosine kinase adaptor protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nck2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- binding protein
- SH3 domain
- Src homology 2 (SH2) domain
- phosphotyrosine binding
- protein binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Nck2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- Alzheimer disease
- limited systemic sclerosis
- drug dependence
- measles
- osteopenia
role in cell
- activation in
- cell death
- proliferation
- expression in
- phosphorylation in
- inactivation in
- formation
- polymerization
- migration
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- Nucleus
- Endoplasmic Reticulum
- cytosol
- vesicle membrane
- synapse
- perikaryon
- postsynaptic density
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nck2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal complex assembly
- signal transduction
- epidermal growth factor receptor signaling pathway
- negative regulation of cell proliferation
- T cell activation
- actin filament organization
- positive regulation of T cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- dendritic spine development
- immunological synapse formation
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of actin filament polymerization
- ephrin receptor signaling pathway
- lamellipodium assembly
- cell migration
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytoplasm
- vesicle membrane
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- scaffold protein binding
- cytoskeletal adaptor activity
- protein binding
- signaling adaptor activity
- receptor tyrosine kinase binding
- receptor signaling complex scaffold activity