Aldh3a2 Gene Summary [Mouse]

Enables aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in several processes, including hexadecanal metabolic process; nervous system development; and terpenoid metabolic process. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including alimentary system; decidua; early conceptus; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome. Orthologous to human ALDH3A2 (aldehyde dehydrogenase 3 family member A2). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Aldh3a2
Official Name
aldehyde dehydrogenase family 3, subfamily A2 [Source:MGI Symbol;Acc:MGI:1353452]
Ensembl ID
ENSMUSG00000010025
Bio databases IDs NCBI: 11671 Ensembl: ENSMUSG00000010025
Aliases aldehyde dehydrogenase family 3, subfamily A2
Synonyms Ahd-3, Ahd-3r, aldehyde dehydrogenase family 3, subfamily A2, Aldh4, Aldh4-r, FALDH, Fatty Aldehyde Dehydrogenase
Species
Mouse, Mus musculus

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aldh3a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Aldehyde dehydrogenase family
  • aldehyde dehydrogenase (NAD)
  • long-chain-aldehyde dehydrogenase
  • aldehyde dehydrogenase
  • long-chain-alcohol oxidase
  • protein homodimerization
  • enzyme
  • methylmalonic acid semialdehyde dehydrogenase
  • NAD(P)+-dependent aldehyde dehydrogenase superfamily

Pathways

Biological processes and signaling networks where the Aldh3a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hyperkeratosis
  • skin barrier defect
regulated by
regulates
  • HMOX1
  • GCLM
  • GCLC
  • D-sphingosine
  • colfosceril palmitate
  • d18:1/50:3 omega-O-linoleoyl-ceramide
  • d18:1/34:0 omega-hydroxyceramide
  • 36:3 triglyceride
  • d18:1/52:3 omega-O-linoleoyl-ceramide
  • d18:1/36:1 omega-hydroxyceramide
role in cell
  • expression in
  • proliferation
  • metabolism in
  • oxidative stress response
  • conversion in
  • width

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • intracellular membrane-bounded organelle
  • cellular membrane
  • Endoplasmic Reticulum
  • endoplasmic reticulum membrane
  • peroxisomes

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.