Tbx3 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including atrioventricular canal morphogenesis; embryonic morphogenesis; and regulation of protein complex stability. Acts upstream of or within several processes, including circulatory system development; mammary gland morphogenesis; and regulation of DNA-templated transcription. Located in nucleus. Part of transcription regulator complex. Is active in cilium. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study ulnar-mammary syndrome. Human ortholog(s) of this gene implicated in ulnar-mammary syndrome. Orthologous to human TBX3 (T-box transcription factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tbx3 |
| Official Name | T-box 3 [Source:MGI Symbol;Acc:MGI:98495] |
| Ensembl ID | ENSMUSG00000018604 |
| Bio databases IDs | |
| Aliases | T-box 3 |
| Synonyms | D5Ertd189e, LOC100047200, T-box 3, T-box transcription factor 3, TBX3-ISO, UMS, XHL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- T-box
- double-stranded DNA binding
- DNA-binding domain of the T-box transcription factor family
- T-box transcription factor
- transcription factor activity
- T-box domain
Pathways
Biological processes and signaling networks where the Tbx3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- developmental delay
- ulnar-mammary syndrome
- epithelial uterine cancer
- benign prostatic hyperplasia
- lower urinary tract symptom
role in cell
- activation in
- migration
- invasion by
- expression in
- apoptosis
- production in
- cell viability
- proliferation
- cell cycle progression
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cilia
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cardiac muscle cell fate commitment
- branching involved in mammary gland duct morphogenesis
- hepatoblast differentiation
- embryonic digit morphogenesis
- skeletal system development
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- heart looping
- ureteric peristalsis
- female genitalia development
- cell fate specification
- embryonic forelimb morphogenesis
- embryonic hindlimb morphogenesis
- mammary placode formation
- stem cell maintenance
- anterior/posterior axis specification, embryo
- cardiac epithelial to mesenchymal transition
- organ morphogenesis
- negative regulation of epithelial cell differentiation
- male genitalia development
- negative regulation of myoblast differentiation
- positive regulation of stem cell proliferation
- mesoderm morphogenesis
- luteinizing hormone secretion
- positive regulation of cell proliferation
- cellular senescence
- palate development
- endocardial cushion formation
- outflow tract morphogenesis
- positive regulation of cell cycle
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- smooth muscle cell differentiation
- blood vessel development
- stem cell proliferation
- negative regulation of stem cell differentiation
- specification of organ position
- forelimb morphogenesis
- negative regulation of cell proliferation involved in heart morphogenesis
- transcription, DNA-dependent
- follicle-stimulating hormone secretion
- atrioventricular bundle cell differentiation
- limbic system development
- ventricular septum morphogenesis
- sinoatrial node cell development
- regulation of transcription from RNA polymerase II promoter
- mammary gland development
- regulation of protein stability
- semicircular canal morphogenesis
- negative regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cilium
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity