Esyt2 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in endocytosis; endoplasmic reticulum-plasma membrane tethering; and lipid transport. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including aorta; genitourinary system; mammary gland; nervous system; and retina. Orthologous to human ESYT2 (extended synaptotagmin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Esyt2 |
| Official Name | extended synaptotagmin-like protein 2 [Source:MGI Symbol;Acc:MGI:1261845] |
| Ensembl ID | ENSMUSG00000021171 |
| Bio databases IDs | |
| Aliases | extended synaptotagmin-like protein 2 |
| Synonyms | 2410017M09Rik, 4921504I16Rik, CHR2SYT, D12Ertd551e, extended synaptotagmin 2, extended synaptotagmin-like protein 2, FAM62B, KIAA1228, LOC102549308, RGD1565705 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Esyt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- binding protein
- phosphatidylethanolamine binding
- Synaptotagmin-like mitochondrial-lipid-binding domain
- calcium ion binding
- calcium-dependent phospholipid binding
- protein binding
- synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain superfamily
- Protein kinase C conserved region 2 (CalB)
- identical protein binding
- phosphatidylinositol binding
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- IgA nephropathy
role in cell
- phosphorylation in
- accumulation in
- production in
- fusion
- cytotoxicity
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- cytoplasmic face of plasma membrane
- endoplasmic reticulum membrane
- organelle membrane contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Esyt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- endocytosis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- organelle membrane contact site
- membrane
- cytosol
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- phosphatidylethanolamine binding
- protein binding
- cadherin binding
- calcium ion binding
- phosphatidylinositol binding
- phosphatidylcholine binding
- calcium-dependent phospholipid binding