Ntsr2 Gene Summary [Mouse]
Enables G protein-coupled neurotensin receptor activity. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway and regulation of membrane potential. Located in membrane. Orthologous to human NTSR2 (neurotensin receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ntsr2 |
| Official Name | neurotensin receptor 2 [Source:MGI Symbol;Acc:MGI:108018] |
| Ensembl ID | ENSMUSG00000020591 |
| Bio databases IDs | |
| Aliases | neurotensin receptor 2 |
| Synonyms | Neurotensin receptor, neurotensin receptor 2, NT2R, NT-R-2, NTRL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ntsr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled neurotensin receptor
- binding protein
- 7 transmembrane receptor (rhodopsin family)
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ntsr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
- Huntington disease
- gait disturbance
- allergic rhinoconjunctivitis
role in cell
- expression in
- phosphorylation in
- apoptosis
- cell viability
- cisplatin sensitivity
- growth
- signaling in
- long term synaptic depression
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear Golgi regions
- cell surface
- cellular membrane
- synaptic membrane
- trans Golgi network
- nerve ending
- perikaryon
- axons
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ntsr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- regulation of membrane potential
- cell surface receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- sensory perception
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled neurotensin receptor activity