NTSR2 Gene Summary [Human]
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NTSR2 |
| Official Name | neurotensin receptor 2 [Source:HGNC Symbol;Acc:HGNC:8040] |
| Ensembl ID | ENSG00000169006 |
| Bio databases IDs | |
| Aliases | neurotensin receptor 2 |
| Synonyms | Neurotensin receptor, neurotensin receptor 2, NT2R, NT-R-2, NTRL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NTSR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled neurotensin receptor
- binding protein
- 7 transmembrane receptor (rhodopsin family)
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the NTSR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
- Huntington disease
- gait disturbance
- allergic rhinoconjunctivitis
role in cell
- expression in
- phosphorylation in
- apoptosis
- cell viability
- cisplatin sensitivity
- growth
- signaling in
- long term synaptic depression
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear Golgi regions
- cell surface
- cellular membrane
- synaptic membrane
- trans Golgi network
- nerve ending
- perikaryon
- axons
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NTSR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- regulation of membrane potential
- cell surface receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- sensory perception
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled neurotensin receptor activity