Zfhx3 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of cell adhesion; regulation of gene expression; and regulation of locomotor rhythm. Located in mitochondrion. Is expressed in several structures, including central nervous system; eye; foot; genitourinary system; and lung. Human ortholog(s) of this gene implicated in familial atrial fibrillation; hepatocellular carcinoma; lung non-small cell carcinoma (multiple); prostate cancer; and spinocerebellar ataxia type 4. Orthologous to human ZFHX3 (zinc finger homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfhx3 |
| Official Name | zinc finger homeobox 3 [Source:MGI Symbol;Acc:MGI:99948] |
| Ensembl ID | ENSMUSG00000038872 |
| Bio databases IDs | |
| Aliases | zinc finger homeobox 3 |
| Synonyms | A230102L03RIK, ATBF1, ATBT, ATFB8, C16orf47, LOC100289496, LOC101927998, LOC108353193, mKIAA4228, RGD1560268, SCA4, Sci, WBP9, ZFH-3, zinc finger homeobox 3, ZNF927 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfhx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- enzyme binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Pathways
Biological processes and signaling networks where the Zfhx3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- metastasis
- breast cancer
- dementia
- non-insulin-dependent diabetes mellitus
- multiple sclerosis
- stroke
- prostatic carcinoma
- prostate cancer
role in cell
- expression in
- phosphorylation in
- proliferation
- autophagy in
- accumulation
- differentiation
- cell cycle progression
- accumulation in
- formation
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfhx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- negative regulation of transcription from RNA polymerase II promoter
- circadian regulation of gene expression
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- regulation of neuron differentiation
- positive regulation of cell adhesion
- positive regulation of transcription from RNA polymerase II promoter
- response to transforming growth factor beta stimulus
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- nuclear body
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- enzyme binding