Klhl29 Gene Summary [Mouse]

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human KLHL29 (kelch like family member 29). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Klhl29
Official Name
kelch-like 29 [Source:MGI Symbol;Acc:MGI:2683857]
Ensembl ID
ENSMUSG00000020627
Bio databases IDs NCBI: 208439 Ensembl: ENSMUSG00000020627
Aliases kelch-like 29
Synonyms A230106N14Rik, FLJ14106, Gm68, KBTBD9, kelch-like 29, kelch-like family member 29, mKIAA1921
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Galactose oxidase, central domain
  • Kelch motif
  • BTB And C-terminal Kelch
  • Broad-Complex, Tramtrack and Bric a brac
  • BTB_POZ
  • BTB/POZ domain
  • protein binding
  • BACK (BTB and C-terminal Kelch) domain
  • Kelch domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hypertension
  • generalized epilepsy
  • neuroticism
  • Parkinson disease
  • conotruncal heart malformations
  • schizophrenia
  • group 3 medulloblastoma
  • brain cancer
  • psychosis
regulated by
role in cell
  • growth

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Unknown

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl29 gene, providing context for its role in the cell.

Molecular Function

What the gene product does at the molecular level
  • protein binding