Klhl21 Gene Summary [Mouse]
Predicted to enable cullin family protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including chromosome passenger complex localization to spindle midzone; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in polar microtubule. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human KLHL21 (kelch like family member 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl21 |
| Official Name | kelch-like 21 [Source:MGI Symbol;Acc:MGI:1919288] |
| Ensembl ID | ENSMUSG00000073700 |
| Bio databases IDs | |
| Aliases | kelch-like 21 |
| Synonyms | 1810045K06Rik, D330008A20, kelch-like 21, kelch-like family member 21, KIAA0469, mKIAA0469, RGD1305863 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- ubiquitin-protein transferase activity
- BTB/POZ domain
- enzyme
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- obesity
- Waldenström macroglobulinemia
- diabetes mellitus
- overnutrition
role in cell
- expression in
- phosphorylation in
- formation
- formation in
- degradation in
- prometaphase
- cytokinesis
- cytokinesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- polar microtubule
- central spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of cytokinesis
- chromosome passenger complex localization to spindle midzone
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- polar microtubule
- cytosol
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding