Glud1 Gene Summary [Mouse]
Enables glutamate dehydrogenase (NAD+) activity. Involved in glutamine metabolic process and tricarboxylic acid metabolic process. Acts upstream of or within positive regulation of insulin secretion. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Glud1 |
| Official Name | glutamate dehydrogenase 1 [Source:MGI Symbol;Acc:MGI:95753] |
| Ensembl ID | ENSMUSG00000021794 |
| Bio databases IDs | |
| Aliases | glutamate dehydrogenase 1 |
| Synonyms | Ac2-281, GDH, GDH1, Gdh-X, GLDH3, GLUD, Gludeha, Gludl, Glutamate Dehydrogenase, glutamate dehydrogenase 1, hGDH1, MRG-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Glud1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- glutamate dehydrogenase [NAD(P)]
- ADP binding
- Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
- enzyme binding
- enzyme
- protein binding
- Glu/Leu/Phe/Val dehydrogenase, dimerization domain
- amino acid binding
- GTP binding
- NAD or NADH binding
- binding protein
- glutamate dehydrogenase
- protein homodimerization
Pathways
Biological processes and signaling networks where the Glud1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gout
- gastrointestinal neoplasia
- hepatocellular carcinoma
- colorectal neoplasia
- epithelial cancer
- chronic sinusitis
- Reye syndrome
- liver cancer
- hyperinsulinism-hyperammonemia syndrome
regulated by
- D-glucose
- adenosine triphosphate
- ADP
- hydrogen peroxide
- CTNNB1
- beta-estradiol
- guanosine triphosphate
- leucine
- epithelial cells
- amiodarone
role in cell
- apoptosis
- cell death
- phosphorylation in
- expression in
- survival
- binding in
- production in
- proliferation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- mitochondrial matrix
- cytoplasmic droplets
- peroxisomal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Glud1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamate catabolic process
- tricarboxylic acid metabolic process
- glutamate biosynthetic process
- glutamine metabolic process
- positive regulation of insulin secretion
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrial matrix
- mitochondrion
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- leucine binding
- GTP binding
- ATP binding
- protein binding
- protein homodimerization activity
- glutamate dehydrogenase [NAD(P)+] activity
- glutamate dehydrogenase (NAD+) activity
- ADP binding
- glutamate dehydrogenase (NADP+) activity
- NAD+ binding