Fkbp1b Gene Summary [Mouse]
Enables FK506 binding activity; peptidyl-prolyl cis-trans isomerase activity; and transmembrane transporter binding activity. Involved in negative regulation of heart rate; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; and regulation of ryanodine-sensitive calcium-release channel activity. Acts upstream of or within several processes, including insulin secretion; negative regulation of insulin secretion involved in cellular response to glucose stimulus; and neuronal action potential propagation. Located in sarcoplasmic reticulum membrane. Part of calcium channel complex. Is expressed in male reproductive gland or organ and nervous system. Used to study catecholaminergic polymorphic ventricular tachycardia. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fkbp1b |
| Official Name | FK506 binding protein 1b [Source:MGI Symbol;Acc:MGI:1336205] |
| Ensembl ID | ENSMUSG00000020635 |
| Bio databases IDs | |
| Aliases | FK506 binding protein 1b |
| Synonyms | 12.6kDa, Calstabin, calstabin2, Fk506 binding, FK506 binding protein 1b, FKBP12.6, FKBP1L, FKBP prolyl isomerase 1B, OTK4, PKBP1L, PPIase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fkbp1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FKBP-type peptidyl-prolyl cis-trans isomerase
- cyclic nucleotide binding
- calcium channel inhibitor
- channel regulator
- peptidylprolyl isomerase
- FK506 binding
- ion channel binding
- enzyme
- protein binding
- receptor binding
- calcium channel regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- ventricular tachycardia
- fatigue
- cardiac hypertrophy
- Turner syndrome
- Klinefelter syndrome
- hyperinsulinism
- arrhythmia
- spatial memory impairment
- psoriasis
role in cell
- proliferation
- cell viability
- function
- elevation in
- regeneration
- afterhyperpolarization in
- afterhyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- cellular membrane
- sarcoplasmic reticulum
- sarcoplasmic reticulum vesicle
- Z line
- sarcoplasmic reticulum membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fkbp1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of insulin secretion involved in cellular response to glucose stimulus
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- insulin secretion involved in cellular response to glucose stimulus
- protein maturation by protein folding
- negative regulation of calcium-mediated signaling
- response to vitamin E
- cytosolic calcium ion homeostasis
- negative regulation of release of sequestered calcium ion into cytosol
- protein peptidyl-prolyl isomerization
- response to hydrogen peroxide
- protein refolding
- 'de novo' protein folding
- elevation of cytosolic calcium ion concentration
- response to redox state
- positive regulation of axon regeneration
- smooth muscle contraction
- positive regulation of sequestering of calcium ion
- T cell proliferation
- negative regulation of heart rate
- release of sequestered calcium ion into cytosol
- neuronal action potential propagation
- calcium-mediated signaling
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Cellular Component
Where in the cell the gene product is active
- Z disc
- calcium channel complex
- cytoplasm
- membrane
- cytosol
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- ryanodine-sensitive calcium-release channel activity
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- FK506 binding
- cyclic nucleotide binding
- receptor binding
- ion channel binding
- channel regulator activity
- calcium channel inhibitor activity