Unk Gene Summary [Mouse]
Enables mRNA CDS binding activity and ribosome binding activity. Acts upstream of or within in utero embryonic development and neuron migration. Predicted to be located in cytoplasm. Is expressed in central nervous system; early conceptus; future brain; oocyte; and retina nuclear layer. Orthologous to human UNK (unk zinc finger). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Unk |
| Official Name | unkempt family zinc finger [Source:MGI Symbol;Acc:MGI:2442456] |
| Ensembl ID | ENSMUSG00000020770 |
| Bio databases IDs | |
| Aliases | unkempt family zinc finger |
| Synonyms | B230379M23Rik, mKIAA1753, UNKEMPT, unkempt family zinc finger, Unkh, unk zinc finger, ZC3H5, ZC3HDC5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Unk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger
- Bacterial type III secretion protein (HrpB7)
- Ezrin/radixin/moesin, alpha-helical domain
- Unkempt Zinc finger domain 1 (Znf1)
- mRNA binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ribosome binding
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- transporter
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Unk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- in utero embryonic development
- cell morphogenesis involved in neuron differentiation
- negative regulation of cytoplasmic translation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- metal ion binding