Ppid Gene Summary [Mouse]
Predicted to enable several functions, including cyclosporin A binding activity; heat shock protein binding activity; and nuclear estrogen receptor binding activity. Predicted to be involved in several processes, including cellular response to UV-A; positive regulation of viral genome replication; and protein peptidyl-prolyl isomerization. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytosol. Is expressed in embryo. Orthologous to human PPID (peptidylprolyl isomerase D). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ppid |
| Official Name | peptidylprolyl isomerase D (cyclophilin D) [Source:MGI Symbol;Acc:MGI:1914988] |
| Ensembl ID | ENSMUSG00000027804 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase D (cyclophilin D) |
| Synonyms | 4930564J03Rik, CYCLOPHILIN40, Cyclophilin d, CYP-40, CYPD, peptidylprolyl isomerase D, peptidylprolyl isomerase D (cyclophilin D), Ppidl |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppid often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- peptidylprolyl isomerase
- cyclophilin
- heat shock protein binding
- cyclosporin A binding
- enzyme binding
- transcription factor binding
- enzyme
- estrogen receptor binding
- protein binding
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- FK506 binding
- Tetratricopeptide repeats
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the Ppid gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphomagenesis
- prostate cancer
- experimental autoimmune encephalomyelitis
- meningioma
- meningeal neoplasia
- peripheral arterial disease
- lymphoma
- Waldenström macroglobulinemia
role in cell
- cell death
- apoptosis
- proliferation
- expression in
- cell viability
- activity
- motility
- depolarization
- depolarization in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- Cytoplasm
- cilia
- perinuclear region
- Mitochondria
- cytosol
- mitochondrial membrane
- nucleoplasm
- nucleoli
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppid gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- protein transport
- chaperone-mediated protein folding
- protein peptidyl-prolyl isomerization
- protein folding
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to UV-A
- release of virus from host
- positive regulation of apoptotic process
- apoptotic process
- lipid particle organization
- positive regulation of protein secretion
- positive regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- heat shock protein binding
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- Hsp90 protein binding
- transcription factor binding
- estrogen receptor binding
- Hsp70 protein binding