Arhgap5 Gene Summary [Mouse]
Predicted to enable GTPase activator activity and SH2 domain binding activity. Acts upstream of or within several processes, including positive regulation of epithelial cell migration; positive regulation of mesenchymal cell proliferation; and regulation of cell size. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ARHGAP5 (Rho GTPase activating protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Arhgap5 |
| Official Name | Rho GTPase activating protein 5 [Source:MGI Symbol;Acc:MGI:1332637] |
| Ensembl ID | ENSMUSG00000035133 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 5 |
| Synonyms | AU014947, GFI2, LRRGT00098, p190-B, p190BRhoGAP, p190Rhogap, p190RhoGAP-A, p190RhoGAP-B, RhoGAP5, Rho GTPase Activating Protein 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- p120rasgap binding domain
- Contains two conserved F residues
- SH2-domain binding
- Ras family
- GTPase
- GTPase activator
- enzyme
- protein binding
- RhoGAP
- GTPase-activator protein for Rho-like GTPases
- FF domain
- Rab subfamily of small GTPases
- pseudoGTPase domain found in the family of p190RhoGAP
- P-loop containing Nucleoside Triphosphate Hydrolases
- p190-A and -B Rho GAPs FF domain
Pathways
Biological processes and signaling networks where the Arhgap5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- uterine neoplasm
- neoplasia
- COVID-19
- tumorigenesis
- Martsolf syndrome
- Hutchinson-Gilford progeria syndrome
- Vogt-Koyanagi-Harada disease
role in cell
- phosphorylation in
- expression in
- proliferation
- activation
- contractility
- adhesion
- size
- neuritogenesis
- migration by
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- Endoplasmic Reticulum
- actin filaments
- cytosol
- dendritic spines
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mammary gland development
- regulation of small GTPase mediated signal transduction
- regulation of cell size
- positive regulation of mesenchymal cell proliferation
- cell adhesion
- positive regulation of epithelial cell migration
- Rho protein signal transduction
- epithelial cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activity
- GTPase activator activity
- SH2 domain binding