Krt12 Gene Summary [Mouse]
Predicted to enable structural molecule activity. Involved in cornea development in camera-type eye and morphogenesis of an epithelium. Acts upstream of or within epithelium development. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in cornea; cornea epithelium; head; lower jaw molar; and upper jaw molar. Used to study Meesmann corneal dystrophy. Human ortholog(s) of this gene implicated in Meesmann corneal dystrophy 1 and corneal dystrophy. Orthologous to human KRT12 (keratin 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt12 |
| Official Name | keratin 12 [Source:MGI Symbol;Acc:MGI:96687] |
| Ensembl ID | ENSMUSG00000020912 |
| Bio databases IDs | |
| Aliases | keratin 12 |
| Synonyms | K12, Ka12, keratin 12, KRT1-12, MECD1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Krt12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Intermediate filament protein
Pathways
Biological processes and signaling networks where the Krt12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Krt12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- morphogenesis of an epithelium
- visual perception
- cornea development in camera-type eye
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- extracellular vesicular exosome
- cytosol
- intermediate filament
Molecular Function
What the gene product does at the molecular level
- structural molecule activity