Uchl5 Gene Summary [Mouse]
Predicted to enable cysteine-type deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Involved in several processes, including brain development; positive regulation of DNA metabolic process; and telomere maintenance. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of Ino80 complex and cytosolic proteasome complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; nose; and salivary gland primordium. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uchl5 |
| Official Name | ubiquitin carboxyl-terminal esterase L5 [Source:MGI Symbol;Acc:MGI:1914848] |
| Ensembl ID | ENSMUSG00000018189 |
| Bio databases IDs | |
| Aliases | ubiquitin carboxyl-terminal esterase L5 |
| Synonyms | 5830413B11Rik, CGI-70, INO80R, ubiquitin carboxyl-terminal esterase L5, ubiquitin C-terminal hydrolase L5, UCH37 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uchl5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin carboxyl-terminal hydrolases
- endopeptidase inhibitor
- binding protein
- peptidase
- ubiquitin-specific protease
- protein binding
- cysteine peptidase C12
Pathways
Biological processes and signaling networks where the Uchl5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- cancer
- osteosarcoma
- osteosarcomagenesis
- diffuse large B-cell lymphoma
- breast cancer
- sarcoma
- cannabis dependence
- obesity
role in cell
- expression in
- apoptosis
- phosphorylation in
- degradation in
- activation in
- replication in
- cell cycle progression
- organization
- ubiquitination in
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- synaptosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uchl5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- positive regulation of DNA repair
- DNA repair
- regulation of proteasomal protein catabolic process
- regulation of chromosome organization
- regulation of DNA strand elongation
- regulation of DNA repair
- DNA recombination
- regulation of embryonic development
- telomere maintenance
- regulation of DNA replication
- forebrain morphogenesis
- ubiquitin-dependent protein catabolic process
- chromatin remodeling
- midbrain development
- lateral ventricle development
- positive regulation of transcription, DNA-dependent
- positive regulation of smoothened signaling pathway
- regulation of cell cycle
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- cytosolic proteasome complex
- Ino80 complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- RNA binding
- protein binding
- endopeptidase inhibitor activity
- proteasome binding