Zfp36l1 Gene Summary [Mouse]
Enables mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including 3'-UTR-mediated mRNA destabilization; cellular response to cAMP; and cellular response to raffinose. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and post-transcriptional regulation of gene expression. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp36l1 |
| Official Name | zinc finger protein 36, C3H type-like 1 [Source:MGI Symbol;Acc:MGI:107946] |
| Ensembl ID | ENSMUSG00000021127 |
| Bio databases IDs | |
| Aliases | zinc finger protein 36, C3H type-like 1 |
| Synonyms | Berg36, BRF1, Butyrate Response Factor, Butyrate response factor 1, cMG1, D530020L18RIK, ERF-1, RNF162B, TIS11B, ZFP36 ring finger protein like 1, zinc finger protein 36, C3H type-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp36l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger
- transcription regulator
- mRNA 3' UTR binding
- mRNA binding
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- zinc finger domain
- Tis11B like protein, N terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- cleft lip
- bladder neoplasia
- amyotrophic lateral sclerosis
- urothelial carcinoma
- urothelial cancer
- anemia
- rheumatoid arthritis
- hypertension
role in cell
- expression in
- proliferation
- migration
- apoptosis
- differentiation
- response by
- decay in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic mRNA processing body
- Cytoplasm
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp36l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- neural tube development
- cell proliferation
- 3'-UTR-mediated mRNA destabilization
- nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- response to wounding
- regulation of stem cell proliferation
- positive regulation of fat cell differentiation
- regulation of mRNA stability
- vasculogenesis
- negative regulation of erythrocyte differentiation
- cellular response to insulin stimulus
- regulation of translation
- MAPK cascade
- cellular response to salt stress
- heart development
- protein kinase B signaling cascade
- regulation of keratinocyte proliferation
- cellular response to peptide hormone stimulus
- apoptotic process
- cellular response to tumor necrosis factor
- cellular response to hypoxia
- mesendoderm development
- mRNA transport
- regulation of keratinocyte differentiation
- p38MAPK cascade
- T cell differentiation in thymus
- cellular response to fibroblast growth factor stimulus
- regulation of B cell differentiation
- mRNA processing
- proepicardium development
- chorio-allantoic fusion
- positive regulation of monocyte differentiation
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- ERK1 and ERK2 cascade
- cellular response to transforming growth factor beta stimulus
- regulation of myoblast differentiation
- cellular response to glucocorticoid stimulus
- cellular response to epidermal growth factor stimulus
- cellular response to cAMP
- regulation of gene expression
- regulation of mRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytoplasmic mRNA processing body
- cytosol
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- mRNA 3'-UTR AU-rich region binding
- metal ion binding
- mRNA binding
- 14-3-3 protein binding