Sf1 Gene Summary [Mouse]
Enables RNA binding activity. Acts upstream of or within several processes, including Leydig cell differentiation; male sex determination; and nuclear body organization. Located in nuclear body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and sensory organ. Orthologous to human SF1 (splicing factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sf1 |
| Official Name | splicing factor 1 [Source:MGI Symbol;Acc:MGI:1095403] |
| Ensembl ID | ENSMUSG00000024949 |
| Bio databases IDs | |
| Aliases | splicing factor 1 |
| Synonyms | AC127556.1, BBP, D11S636, MBBP, MZFM, splicing factor 1, WBP4, ZCCHC25, ZFM1, ZFP162, ZNF162 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc knuckle
- zinc finger
- transcription regulator
- Splicing factor 1 helix-hairpin domain
- K homology (KH) RNA-binding domain, type I
- KH domain
- transcription co-repressor
- proline glycine methionine motif
- protein binding
- K homology RNA-binding domain
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- myasthenia gravis
- neurodevelopmental disorder
- paroxysmal nocturnal hemoglobinuria
- germ cell neoplasia
role in cell
- expression in
- migration
- growth
- organization
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- spliceosomes
- nucleoplasm
- nuclear bodies
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male sex determination
- negative regulation of transcription, DNA-dependent
- regulation of nuclear mRNA splicing, via spliceosome
- negative regulation of smooth muscle cell proliferation
- regulation of steroid biosynthetic process
- Leydig cell differentiation
- nuclear body organization
- nuclear mRNA 3'-splice site recognition
- spliceosomal complex assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- spliceosomal complex
- ribosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- protein binding
- RNA binding
- transcription corepressor activity
- mRNA binding