Mapkapk2 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in several processes, including macropinocytosis; regulation of cytokine production; and response to lipopolysaccharide. Acts upstream of or within inner ear development; p38MAPK cascade; and positive regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapkapk2 |
| Official Name | MAP kinase-activated protein kinase 2 [Source:MGI Symbol;Acc:MGI:109298] |
| Ensembl ID | ENSMUSG00000016528 |
| Bio databases IDs | |
| Aliases | MAP kinase-activated protein kinase 2 |
| Synonyms | MAPK activated protein kinase 2, Mapkap2, MAPKAP Kinase 2, MAP kinase-activated protein kinase 2, MK-2, Rps6kc1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapkapk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Sumoylation motif
- nuclear export signal
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- MAPK binding site
- nuclear localization sequence
- common docking domain
- protein binding
- Protein kinase domain
- proline rich domain
- Sh3 domain binding motif
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Mapkapk2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- Crohn disease
- breast cancer
- COVID-19
- right ventricular hypertrophy
role in cell
- growth
- expression in
- phosphorylation in
- apoptosis
- cell death
- formation
- proliferation
- quantity
- activation in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- basal bodies
- centrosome
- cytosol
- nucleoplasm
- synaptosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapkapk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- inner ear development
- regulation of cellular response to heat
- protein autophosphorylation
- regulation of mRNA stability
- protein phosphorylation
- positive regulation of macrophage cytokine production
- MAPK cascade
- inflammatory response
- positive regulation of tumor necrosis factor production
- intracellular signal transduction
- 3'-UTR-mediated mRNA stabilization
- p38MAPK cascade
- leukotriene metabolic process
- regulation of tumor necrosis factor production
- response to DNA damage stimulus
- toll-like receptor signaling pathway
- vascular endothelial growth factor receptor signaling pathway
- macropinocytosis
- regulation of tumor necrosis factor-mediated signaling pathway
- regulation of interleukin-6 production
- response to lipopolysaccharide
- cellular response to vascular endothelial growth factor stimulus
- peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- extracellular vesicular exosome
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- protein binding
- calmodulin-dependent protein kinase activity
- protein kinase activity
- protein serine/threonine kinase activity
- mitogen-activated protein kinase binding
- calcium-dependent protein serine/threonine kinase activity