Slc17a1 Gene Summary [Mouse]
Predicted to enable transmembrane transporter activity. Predicted to be involved in sodium-dependent phosphate transport; urate metabolic process; and urate transport. Predicted to be active in apical plasma membrane. Is expressed in cortical renal tubule and lower jaw molar. Orthologous to human SLC17A1 (solute carrier family 17 member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc17a1 |
| Official Name | solute carrier family 17 (sodium phosphate), member 1 [Source:MGI Symbol;Acc:MGI:103209] |
| Ensembl ID | ENSMUSG00000021335 |
| Bio databases IDs | |
| Aliases | solute carrier family 17 (sodium phosphate), member 1 |
| Synonyms | NAPI-1, NPT-1, Sodium/Phosphate CoTransporter1, solute carrier family 17 member 1, solute carrier family 17 (sodium phosphate), member 1, Vglut1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc17a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoglycerate transporter family protein
- Multidrug resistance protein
- Major Facilitator Superfamily
- Na(+)-dependent inorganic phosphate cotransporter
- sodium:phosphate symporter
- transporter
Pathways
Biological processes and signaling networks where the Slc17a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
- major depression
- psoriasis
- irritable bowel syndrome
- metabolic syndrome X
- progressive familial intrahepatic cholestasis type 1
- insomnia
- systemic lupus erythematosus
regulates
- L-glutamic acid
- uric acid
- aspirin
- p-aminohippuric acid
- phosphate
- ion
role in cell
- transport in
- neurotransmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- synaptic vesicles
- nerve ending
- synaptosomes
- synapse
- secretory granules
- brush border
- membrane processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc17a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- phosphate ion transport
- sodium-dependent phosphate transport
- sodium ion transmembrane transport
- urate transport
- anion transport
- urate metabolic process
- phosphate ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- inorganic phosphate transmembrane transporter activity
- sodium:phosphate symporter activity
- transmembrane transporter activity