Gpd1 Gene Summary [Mouse]
Enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity. Involved in glycerol-3-phosphate shuttle. Acts upstream of or within several processes, including cellular response to cAMP; gluconeogenesis; and positive regulation of glycolytic process. Located in mitochondrion. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; liver; and nervous system. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpd1 |
| Official Name | glycerol-3-phosphate dehydrogenase 1 (soluble) [Source:MGI Symbol;Acc:MGI:95679] |
| Ensembl ID | ENSMUSG00000023019 |
| Bio databases IDs | |
| Aliases | glycerol-3-phosphate dehydrogenase 1 (soluble) |
| Synonyms | Gdc-1, Glycerol-3-phosphate dehydrogenase, glycerol-3-phosphate dehydrogenase 1, glycerol-3-phosphate dehydrogenase 1 (soluble), Glycerolphosphate Dehydrogenase, Glycerophosphate dehydrogenase, Gpd3, GPD-C, GPDH, GPDH-C, HTGTI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- NAD or NADH binding
- NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
- NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
- glycerol-3-phosphate dehydrogenase (NAD)
- glycerol-3-phosphate dehydrogenase [NAD(P)]
- glycerol-3-phosphate dehydrogenase (NAD(+))
- CH-OH group:NAD or NADP oxidoreductase
- glycerol-3-phosphate dehydrogenase
- enzyme
- protein binding
- Bacterial GPD, NAD-dependent C-terminal
Pathways
Biological processes and signaling networks where the Gpd1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- transient infantile hypertriglyceridemia
- breast cancer
- atopic dermatitis
- hereditary disorder
- HER2 negative hormone receptor negative breast cancer
- Huntington disease
- lung adenocarcinoma
role in cell
- expression in
- phosphorylation in
- proliferation
- function
- migration
- response by
- invasion by
- glycolysis in
- function in
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- nuclear scaffolds
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol-3-phosphate metabolic process
- gluconeogenesis
- glycerolipid metabolic process
- glycerol-3-phosphate catabolic process
- cellular response to cAMP
- cellular response to tumor necrosis factor
- glycerophosphate shuttle
- NADH oxidation
- positive regulation of glycolysis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- NAD binding
- glycerol-3-phosphate dehydrogenase activity