Pdzk1 Gene Summary [Mouse]
Predicted to enable PDZ domain binding activity; protein-membrane adaptor activity; and scavenger receptor binding activity. Involved in positive regulation of protein targeting to membrane; protein localization to plasma membrane; and regulation of monoatomic anion transport. Acts upstream of or within in utero embryonic development. Located in brush border membrane. Is expressed in several structures, including genitourinary system; liver; lung; thymus; and white fat. Orthologous to several human genes including PDZK1 (PDZ domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdzk1 |
| Official Name | PDZ domain containing 1 [Source:MGI Symbol;Acc:MGI:1928901] |
| Ensembl ID | ENSMUSG00000038298 |
| Bio databases IDs | |
| Aliases | PDZ domain containing 1 |
| Synonyms | 1700023D20Rik, 2610507N21Rik, 4921513F16Rik, CAP70, CLAMP, D3Ertd537e, mPDZK1, naPi-Cap1, NHERF-3, PDZD1, PDZ domain containing 1, Sodium sulfate cotransporter, Sodium sulphate cotransporter |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdzk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- binding protein
- scavenger receptor binding
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- cpPDZ_RseP_YlbL-like
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell cancer
- psoriasis
- squamous-cell carcinoma
- intellectual disability and developmental delay
- Wilms tumor
- Wilms tumorigenesis
- gout
- global developmental delay with intellectual disability
- trigonocephaly
role in cell
- expression in
- activation in
- phosphorylation in
- binding in
- cell death
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- membrane fraction
- Cytoplasm
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- cytosol
- apical membrane
- basolateral membrane
- brush border
- microvilli
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdzk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein targeting to membrane
- carnitine transport
- positive regulation of ion transmembrane transporter activity
- regulation of anion transport
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- extracellular vesicular exosome
- brush border membrane
- brush border
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein anchor
- PDZ domain binding
- receptor binding
- scavenger receptor binding