Rgs3 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; lung; and nervous system. Orthologous to human RGS3 (regulator of G protein signaling 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs3 |
| Official Name | regulator of G-protein signaling 3 [Source:MGI Symbol;Acc:MGI:1354734] |
| Ensembl ID | ENSMUSG00000059810 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 3 |
| Synonyms | 4930506N09Rik, C2PA, C2PA-RGS3, GRS3, PDZ-RGS3, regulator of G-protein signaling 3, RGP3, RGS3S, SRB-RGS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgs3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology Region 1
- Domain present in PSD-95, Dlg, and ZO-1/2
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- canonical PDZ domain
- GTPase activator
- enzyme
- protein binding
- PDZ domain
- Regulator of G protein signaling domain
- Mucin-like
- Protein kinase C conserved region 2 (CalB)
- C2 domain
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Rgs3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- refractive error
role in cell
- apoptosis
- binding
- phosphorylation in
- expression in
- migration
- accumulation in
- adhesion
- chemotaxis
- cell rounding
- blebbing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- membrane processes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgs3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- G-protein coupled receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activity
- GTPase activator activity