Wrnip1 Gene Summary [Mouse]
Predicted to enable several functions, including ATP hydrolysis activity; identical protein binding activity; and single-stranded DNA helicase activity. Predicted to be involved in DNA synthesis involved in DNA repair; DNA-templated DNA replication; and regulation of DNA-templated DNA replication initiation. Located in nucleus. Is expressed in several structures, including alimentary system; cranial ganglion; cranium; limb; and naris. Orthologous to human WRNIP1 (WRN helicase interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wrnip1 |
| Official Name | Werner helicase interacting protein 1 [Source:MGI Symbol;Acc:MGI:1926153] |
| Ensembl ID | ENSMUSG00000021400 |
| Bio databases IDs | |
| Aliases | Werner helicase interacting protein 1 |
| Synonyms | 4833444L21Rik, bA420G6.2, CFAP93, FAP93, Werner helicase interacting protein 1, WHIP, WRN helicase interacting protein 1, WRNIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wrnip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA C-terminal domain
- DNA polymerase III, delta subunit
- Rad18-like CCHC zinc finger
- MgsA AAA+ ATPase C terminal
- enzyme
- protein binding
- identical protein binding
- ATPase
- AAA domain (dynein-related subfamily)
- Holliday junction DNA helicase RuvB P-loop domain
- ATPase family associated with various cellular activities (AAA)
- helical lid domain of clamp loader-like AAA+ proteins
- Werner helicase-interacting protein 1 ubiquitin-binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear region
- granules
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wrnip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of DNA-dependent DNA replication initiation
- DNA duplex unwinding
- innate immune response
- DNA-dependent DNA replication
- DNA synthesis involved in DNA repair
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- perinuclear region of cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- identical protein binding
- protein binding
- metal ion binding
- enzyme activator activity
- single-stranded DNA-dependent ATP-dependent DNA helicase activity