Atrx Gene Summary [Mouse]
Enables chromatin binding activity and histone binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; cellular response to hydroxyurea; and positive regulation of DNA metabolic process. Acts upstream of or within several processes, including male gonad development; positive regulation of transcription by RNA polymerase II; and post-embryonic forelimb morphogenesis. Located in PML body and chromosome. Colocalizes with chromosome, telomeric region. Is expressed in several structures, including alimentary system; early embryo; egg cylinder; genitourinary system; and nervous system. Used to study alpha thalassemia-X-linked intellectual disability syndrome. Human ortholog(s) of this gene implicated in X-linked mental retardation-hypotonic facies syndrome-1; alpha thalassemia-X-linked intellectual disability syndrome; alpha-thalassemia myelodysplasia syndrome; high grade glioma; and lung small cell carcinoma. Orthologous to human ATRX (ATRX chromatin remodeler). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atrx |
| Official Name | ATRX, chromatin remodeler [Source:MGI Symbol;Acc:MGI:103067] |
| Ensembl ID | ENSMUSG00000031229 |
| Bio databases IDs | |
| Aliases | ATRX, chromatin remodeler |
| Synonyms | 4833408C14RIK, ATR2, ATRX chromatin remodeler, ATRX, chromatin remodeler, DXHXS6677E, Hp1bp2, HP1-BP38, JMS, LOC103690008, MRX52, MRXS3, RAD54, RAD54L, XH2, XNP, ZNF-HX |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atrx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- Cysteine Rich ADD domain
- protein binding activity, bridging
- SNF2-related domain
- helicase superfamily c-terminal domain
- chromatin binding
- protein domain specific binding
- protein binding
- Helicase conserved C-terminal domain
- helicase domain
- FYVE domain like superfamily
- ADD domain
- DNA translocase
- N-terminal helicase domain of the DEAD-box helicase superfamily
- PHD finger superfamily
- DEAD-like helicases superfamily
- DTHCT (NUC029) region
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Atrx gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- polycystic ovary syndrome
- osteosarcoma
- Huntington disease
- cancer
- urothelial bladder carcinoma
- clear-cell ovarian carcinoma
- astrocytoma
- head and neck squamous cell carcinoma
- lung squamous cell carcinoma
role in cell
- quantity
- survival
- expression in
- proliferation
- activation in
- apoptosis
- phosphorylation in
- dysfunction
- dysfunction in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- microtubule cytoskeleton
- ND10 structure
- heterochromatin
- Cytoplasm
- cilia
- basal bodies
- cytosol
- nuclear foci
- chromosome
- nucleoplasm
- nuclear bodies
- nuclear speckles
- nuclear matrix
- PML nuclear bodies
- centromeres
- telomeres
- chromatin
- pericentric heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atrx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- DNA repair
- positive regulation of DNA replication involved in S phase
- spermatogenesis
- transcription from RNA polymerase II promoter
- Sertoli cell development
- regulation of transcription, DNA-dependent
- chromatin organization
- positive regulation of transcription from RNA polymerase II promoter
- chromosome organization involved in meiosis
- meiotic spindle organization
- nucleosome assembly
- chromatin remodeling
- forebrain development
- telomeric heterochromatin assembly
- seminiferous tubule development
- protein localization to chromosome, telomeric region
- DNA damage response, signal transduction by p53 class mediator
- cellular response to hydroxyurea
- replication fork processing
- positive regulation of telomere maintenance
- post-embryonic forelimb morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- heterochromatin
- nuclear body
- PML body
- condensed chromosome, centromeric region
- nuclear chromosome
- centromeric heterochromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- chromatin DNA binding
- ATP binding
- protein binding
- metal ion binding
- histone binding
- methylated histone residue binding
- chromo shadow domain binding
- helicase activity
- DNA translocase activity
- chromatin binding