Caml Gene Summary [Mouse]
Predicted to enable cell adhesion molecule binding activity and ubiquitin protein ligase binding activity. Involved in B cell homeostasis. Acts upstream of or within epidermal growth factor receptor signaling pathway and receptor recycling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of GET complex. Is expressed in central nervous system; dorsal root ganglion; and retina. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIz. Orthologous to human CAMLG (calcium modulating ligand). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Caml |
| Official Name | calcium modulating ligand [Source:MGI Symbol;Acc:MGI:104728] |
| Ensembl ID | ENSMUSG00000021501 |
| Bio databases IDs | |
| Aliases | calcium modulating ligand |
| Synonyms | calcium modulating ligand, CAML, CDG2Z, GET2, T-cell modul |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Caml often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- C-terminal transmembrane domain
- cytoplasmic domain
- cell adhesion molecule binding
- protein binding
- Get2-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- diffuse large B-cell lymphoma
- acute renal failure
- renal failure
- primary rectal adenocarcinoma
- dry eye
- Waldenström macroglobulinemia
- lymphoma
- COVID-19
- transplanted organ rejection
role in cell
- apoptosis
- quantity
- proliferation
- survival
- homeostasis
- destabilization in
- turnover
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Caml gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tail-anchored membrane protein insertion into ER membrane
- vesicle-mediated transport
- signal transduction
- epidermal growth factor receptor signaling pathway
- negative regulation of protein ubiquitination
- protein insertion into ER membrane
- defense response
- protein stabilization
- B cell homeostasis
- receptor recycling
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- GET complex
- cytoplasm
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding