Sec61b Gene Summary [Mouse]
Enables ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation; post-translational protein targeting to membrane, translocation; and retrograde protein transport, ER to cytosol. Located in endoplasmic reticulum quality control compartment. Orthologous to human SEC61B (SEC61 translocon subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sec61b |
| Official Name | Sec61 beta subunit [Source:MGI Symbol;Acc:MGI:1913462] |
| Ensembl ID | ENSMUSG00000053317 |
| Bio databases IDs | |
| Aliases | Sec61 beta subunit |
| Synonyms | 1190006C12RIK, SEC61 beta, SEC61 translocon subunit beta, SEC61 translocon subunit β, SEC61 β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sec61b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hormone binding
- Sec61beta family
- ribosome binding
- protein binding
- growth factor binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- rough endoplasmatic reticulum
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sec61b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SRP-dependent cotranslational protein targeting to membrane, translocation
- retrograde protein transport, ER to cytosol
- posttranslational protein targeting to membrane, translocation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum quality control compartment
- cytosol
- endoplasmic reticulum
- Sec61 translocon complex
- endoplasmic reticulum Sec complex
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- ribosome binding
- guanyl-nucleotide exchange factor activity
- epidermal growth factor binding