Get1 Gene Summary [Mouse]
Predicted to enable protein-membrane adaptor activity. Acts upstream of or within several processes, including otic vesicle development; post-translational protein targeting to endoplasmic reticulum membrane; and sensory perception of sound. Predicted to be located in endoplasmic reticulum. Predicted to be part of GET complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and skeleton. Orthologous to human GET1 (guided entry of tail-anchored proteins factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Get1 |
| Official Name | guided entry of tail-anchored proteins factor 1 [Source:MGI Symbol;Acc:MGI:2136882] |
| Ensembl ID | ENSMUSG00000023147 |
| Bio databases IDs | |
| Aliases | guided entry of tail-anchored proteins factor 1 |
| Synonyms | 5530402J05Rik, C030018G21Rik, CHD5, guided entry of tail-anchored proteins factor 1, WRB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Get1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- coiled-coil domain
- CHD5-like protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Get1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tail-anchored membrane protein insertion into ER membrane
- protein insertion into ER membrane
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- GET complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein anchor