CAMLG Gene Summary [Human]
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CAMLG |
| Official Name | calcium modulating ligand [Source:HGNC Symbol;Acc:HGNC:1471] |
| Ensembl ID | ENSG00000164615 |
| Bio databases IDs | |
| Aliases | calcium modulating ligand, calcium-modulating cyclophilin ligand, calcium-signal modulating cyclophilin ligand, cyclophilin B-binding protein |
| Synonyms | calcium modulating ligand, CAML, CDG2Z, GET2, T-cell modul |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CAMLG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- C-terminal transmembrane domain
- cytoplasmic domain
- cell adhesion molecule binding
- protein binding
- Get2-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- diffuse large B-cell lymphoma
- acute renal failure
- renal failure
- primary rectal adenocarcinoma
- dry eye
- Waldenström macroglobulinemia
- lymphoma
- COVID-19
- transplanted organ rejection
role in cell
- apoptosis
- quantity
- proliferation
- survival
- homeostasis
- destabilization in
- turnover
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CAMLG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tail-anchored membrane protein insertion into ER membrane
- vesicle-mediated transport
- signal transduction
- epidermal growth factor receptor signaling pathway
- negative regulation of protein ubiquitination
- protein insertion into ER membrane
- defense response
- protein stabilization
- B cell homeostasis
- receptor recycling
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- GET complex
- cytoplasm
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding