Depdc1b Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in cell migration and positive regulation of Wnt signaling pathway. Is expressed in genital tubercle; limb; and limb mesenchyme. Orthologous to human DEPDC1B (DEP domain containing 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Depdc1b |
| Official Name | DEP domain containing 1B [Source:MGI Symbol;Acc:MGI:2145425] |
| Ensembl ID | ENSMUSG00000021697 |
| Bio databases IDs | |
| Aliases | DEP domain containing 1B |
| Synonyms | 9830132O03, BRCC3, DEP domain containing 1B, XTP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Depdc1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DEP
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- diabetic nephropathy
- organismal death
- cholangiocarcinoma
- cholangiocarcinoma cancer
- small cell lung cancer
role in cell
- proliferation
- expression in
- apoptosis
- migration
- binding in
- degradation in
- invasion by
- ubiquitination in
- colony formation
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Depdc1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Wnt receptor signaling pathway
- cell migration
- intracellular signal transduction
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity