Copa Gene Summary [Mouse]
Enables mRNA binding activity. Acts upstream of or within protein localization to axon and protein localization to cell leading edge. Located in COPI-coated vesicle; Golgi apparatus; and growth cone. Is expressed in several structures, including brain; jaw bone; and thoracic segment skeleton. Used to study autoimmune interstitial lung, joint, and kidney disease. Human ortholog(s) of this gene implicated in autoimmune interstitial lung, joint, and kidney disease. Orthologous to human COPA (COPI coat complex subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Copa |
| Official Name | coatomer protein complex subunit alpha [Source:MGI Symbol;Acc:MGI:1334462] |
| Ensembl ID | ENSMUSG00000026553 |
| Bio databases IDs | |
| Aliases | coatomer protein complex subunit alpha |
| Synonyms | AIAISD, AILJK, Alpha-coat, Alpha-COP, coatomer protein complex subunit alpha, coatomer protein complex subunit α, COPI coat complex subunit alpha, COPI coat complex subunit α, HEP-COP, xenin, α-coat, α-COP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Copa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coatomer (COPI) alpha subunit C-terminus
- WD40 repeats
- mRNA binding
- WD domain, G-beta repeat
- WD40
- protein binding
- Coatomer WD associated region
- transporter
Pathways
Biological processes and signaling networks where the Copa gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autoimmune interstitial lung, joint and kidney disease
- HER2 negative hormone receptor negative breast cancer
- Hutchinson-Gilford progeria syndrome
- infection by Human parainfluenza virus 3
- infection by vesicular stomatitis virus
- infection by lymphocytic choriomeningitis virus
role in cell
- cell viability
- expression in
- production in
- apoptosis
- frequency
- cell death
- accumulation in
- phosphorylation in
- binding in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Extracellular Space
- Golgi Apparatus
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- growth cone
- transport vesicles
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Copa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- signal transduction
- retrograde vesicle-mediated transport, Golgi to ER
- intra-Golgi vesicle-mediated transport
- intracellular protein transport
- pancreatic juice secretion
Cellular Component
Where in the cell the gene product is active
- growth cone
- endoplasmic reticulum membrane
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- Golgi membrane
- transport vesicle
- COPI vesicle coat
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity
- hormone activity