Scube3 Gene Summary [Mouse]
Predicted to enable BMP binding activity; BMP receptor binding activity; and identical protein binding activity. Involved in positive regulation of osteoblast differentiation. Acts upstream of or within positive regulation of smoothened signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracellular space. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; integumental system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2. Orthologous to human SCUBE3 (signal peptide, CUB domain and EGF like domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scube3 |
| Official Name | signal peptide, CUB domain, EGF-like 3 [Source:MGI Symbol;Acc:MGI:3045253] |
| Ensembl ID | ENSMUSG00000038677 |
| Bio databases IDs | |
| Aliases | signal peptide, CUB domain, EGF-like 3 |
| Synonyms | CEGF3, D030038I21Rik, signal peptide, CUB domain and EGF like domain containing 3, signal peptide, CUB domain, EGF-like 3, SSFSC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scube3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complement Clr-like EGF-like
- Tyrosine-protein kinase ephrin type A/B receptor-like
- cytokine binding
- calcium-binding EGF-like domain
- protein binding
- receptor binding
- identical protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- EGF-like domain
- EGF_CA
- CUB
- EGF domain
- Coagulation Factor Xa inhibitory site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- metastasis
- short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2
- non-small cell lung cancer
- short stature, facial dysmorphism, and skeletal anomalies without cardiac anomalies 2
- lung metastasis
- lung cancer
phenotypes
- abnormal anxiety-related response
- abnormal body composition
- abnormal bone ossification
- abnormal digit morphology
- abnormal enzyme/coenzyme activity
- abnormal food intake
- abnormal heart left ventricle morphology
- abnormal inner ear morphology
- abnormal interventricular septum morphology
- abnormal lumbar vertebrae morphology
- abnormal malleus head morphology
- abnormal malleus morphology
- abnormal metacarpal bone morphology
- abnormal metatarsal bone morphology
- abnormal middle ear morphology
- abnormal middle ear ossicle morphology
- abnormal pectoral girdle bone morphology
- abnormal posture
- abnormal renal filtration
- abnormal tarsal bone morphology
- abnormal temporal bone morphology
- abnormal thoracic vertebrae morphology
- abnormal vertebral pedicle morphology
- conductive hearing loss
- decreased body fat mass
- decreased body size
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating cholesterol level
- decreased circulating free fatty acid level
- decreased circulating glucose level
- decreased circulating glycerol level
- decreased circulating phosphate level
- decreased circulating serum albumin level
- decreased circulating total protein level
- decreased circulating triglyceride level
- decreased grip strength
- decreased lean body mass
- decreased pulmonary respiratory rate
- decreased urine albumin level
- decreased urine creatinine level
- decreased urine glucose level
- decreased urine protein level
- decreased urine uric acid level
- decreased vertical activity
- fused phalanges
- hypoactivity
- improved glucose tolerance
- increased alkaline phosphatase activity
- increased blood urea nitrogen level
- increased blood uric acid level
- increased bone resorption
- increased circulating calcium level
- increased circulating creatinine level
- increased circulating potassium level
- increased fluid intake
- increased or absent threshold for auditory brainstem response
- kinked tail
- no abnormal phenotype detected
- polyuria
- prolonged QRS complex duration
- rib fusion
- short femur
- short tail
- small incus
- small middle ear ossicles
- thin ventricular wall
role in cell
- expression in
- phosphorylation in
- growth
- differentiation
- tubulation
- invasiveness
- signaling in
- epithelial-mesenchymal transition
- mobility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scube3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of BMP signaling pathway
- signal transduction
- positive regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- BMP binding
- identical protein binding
- protein binding
- calcium ion binding
- BMP receptor binding