Cox8a Gene Summary [Mouse]
Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Is expressed in several structures, including alimentary system; liver; nervous system; nose; and urinary system. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 15. Orthologous to human COX8A (cytochrome c oxidase subunit 8A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox8a |
| Official Name | cytochrome c oxidase subunit 8A [Source:MGI Symbol;Acc:MGI:105959] |
| Ensembl ID | ENSMUSG00000035885 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase subunit 8A |
| Synonyms | COX, COX8, COX8-2, COX8L, COX VIII, cytochrome c oxidase subunit 8A, cytochrome c oxidase subunit viii, Cytochrome C Oxidase Subunit Viiia, Cytochrome oxidase subunit 8, MC4DN15, VIII, VIII-L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cox8a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- mitochondrial presequence
- enzyme
- protein binding
- Cyt_c_Oxidase_VIII
Pathways
Biological processes and signaling networks where the Cox8a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Leigh syndrome
- chronic obstructive pulmonary disease
- nuclear type 15 mitochondrial complex IV deficiency
- insulin resistance
- nuclear type 1 mitochondrial complex iv deficiency
role in cell
- formation in
- phosphorylation in
- production in
- binding in
- function
- mitochondrial cell death
- accumulation in
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cox8a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- mitochondrial electron transport, cytochrome c to oxygen
- cellular respiration
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- respiratory chain complex IV
- mitochondrion
- mitochondrial respiratory chain complex IV
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytochrome-c oxidase activity